Here is a look at the clubs most likely to give City a run for their money next season.
A round-up of Saturday's action in the Premier League.
IMAGES from the EPL matches played on Saturday
Manchester City suffered their first home Premier League loss in eight months as a shock 3-2 defeat by Crystal Palace on Saturday left Pep Guardiola's champions trailing leaders Liverpool by four points.
Chelsea beat Manchester City 1-0 on Saturday to book a place in next month's FA Cup final, thanks to a second-half goal by Hakim Ziyech which ended City manager Pep Guardiola's dream of steering his side to an unprecedented quadruple of titles.
Sixth-placed Arsenal slumped to a 3-2 home defeat by West Ham United.\n
The champions beat Aston Villa 2-1 while Manchester United went down 1-2 at home to Blackburn Rovers in the Premier League.
Manchester United's top-four aspirations suffered a setback as Louis van Gaal's side were blown away 3-0 by Everton.
Arsenal delivered a brutal lesson in fast-paced Premier League football to beat Liverpool 4-1 on Saturday, maintaining their faint title aspirations and almost certainly dashing their opponents' hopes of a top-four finish.
Arsenal took the race to the final day last season and are strongly tipped to end Manchester City's dominance this time.
Manchester City maintained their perfect start to the season with a 2-0 victory over promoted Watford as champions Chelsea suffered a shock 2-1 home defeat by Crystal Palace on Saturday.
Chelsea kept up their pursuit of the Premier League's top three clubs with a 1-0 win away to London rivals Crystal Palace on Sunday, thanks to a strike by N'Golo Kante early in the second half.
Frank Lampard hit four goals for Chelsea in a 7-1 demolition of Aston Villa to put the Londoners briefly on top of the English Premier League with 71 points before United responded with a 4-0 win in an evening game at Bolton Wanderers -- Dimitar Berbatov scoring twice for the champions.
A round-up of Tuesday's action in the UEFA Champions League.
Manchester United will all but retain their Premier League title on Saturday if they become the first English side to win at Stamford Bridge for four years. Even if United lose and allow Chelsea to pull level on points, Alex Ferguson's team would stay top with a superior goal difference of plus-54 compared to Chelsea's plus-36.
A summary of Sunday's action in the Premier League.
The Premier League champions have endured a dismal season so far, losing eight of the 16 games they have played in all competitions, and were knocked out of the League Cup, that they also won last season, in a penalty shootout against Stoke City on Tuesday night.
Protests erupted in Minneapolis and other US cities on Tuesday after George Floyd, an African-American man, died following his arrest by the police.
Chelsea beat Manchester City 1-0 with a Michael Essien goal to move back up to second place in the Premier League on Sunday.
Manchester United were humbled 3-0 at home by Newcastle United in the League Cup fourth round
Images from the UEFA Champions League matches on Tuesday night.
Chelsea found no chink in Everton's defensive armour as the Premier League champions were held to a frustrating 0-0 draw at Goodison Park on Saturday.
Chelsea closed the gap on leaders Manchester United to two points by winning 2-0 at Manchester City on Saturday. The victory gave them 74 points from 33 matches and means the pressure will be on United when they travel to Middlesbrough for their game in hand on Sunday.
Runaway Premier League leaders Manchester City beat champions Chelsea 1-0 at the Etihad Stadium on Sunday to extend their lead to 18 points and leave the London side further adrift from the Champions League qualification spots.
IMAGES from the English Premier League matches played on Wednesday.
Three consecutive draws for Chelsea allowed Manchester United to stride into 2007 six points clear at the top of the EPL table.
Manchester United bolstered their squad with a flurry of transfer deadline day signings, Manchester City and Liverpool also splashed out while ambitious Brighton & Hove Albion sealed an audacious loan deal for Barcelona's Ansu Fati on Friday.
Premier League leaders Manchester United outclassed bottom side Watford 4-0 on Wednesday to maintain their six point lead over Chelsea, who beat Blackburn Rovers 3-0.
Manager Andre Villas-Boas criticised referee Chris Foy after his Chelsea team had two players sent off in a shock 1-0 defeat at west London neighbours Queens Park Rangers on Sunday.
News of all that's transpired on and off the football field
The result left Manchester United top of the EPL standings on 35 points, three ahead of Chelsea.
A goal in added time by Diego Costa earned Chelsea a 1-1 draw against Manchester United on Sunday and preserved Guus Hiddink's unbeaten record while denying Dutch compatriot Louis van Gaal victory.
A summary of Saturday's action in the Premier League.
Manchester City won an unprecedented fourth straight English top flight title with a 3-1 win over West Ham United.
Chelsea cut Manchester United's Premier League lead to five points after Didier Drogba scored the winner in a 1-0 victory over Newcastle United on Wednesday.
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
West Ham United and Chelsea both narrowly avoided ignominious FA Cup exits with narrow wins against lower-league opposition but Everton marked Frank Lampard's first game in charge by sauntering past Brentford into the fifth round on Saturday.
Chelsea's hopes of retaining the Premier League title looked forlorn and Carlo Ancelotti's future equally bleak on Wednesday as the champions' fall from grace continued with a 1-0 defeat at Wolverhampton Wanderers.
Third-placed Chelsea will be eager to bounce back from their 1-0 defeat by relegation-threatened West Ham United on Saturday but face a tough test against a Huddersfield side that have won four and drawn two of their eight home league games this season.
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