Manchester United's top-four aspirations suffered a setback as Louis van Gaal's side were blown away 3-0 by Everton.
The champions beat Aston Villa 2-1 while Manchester United went down 1-2 at home to Blackburn Rovers in the Premier League.
Spain manager Luis de la Fuente left Barcelona's 17-year-old defender Pau Cubarsi and midfielders Marcos Llorente and Aleix Garcia out of his 26-man squad
Arsenal delivered a brutal lesson in fast-paced Premier League football to beat Liverpool 4-1 on Saturday, maintaining their faint title aspirations and almost certainly dashing their opponents' hopes of a top-four finish.
Chelsea kept up their pursuit of the Premier League's top three clubs with a 1-0 win away to London rivals Crystal Palace on Sunday, thanks to a strike by N'Golo Kante early in the second half.
A summary of Sunday's action in the Premier League.
IMAGES from the English Premier League matches played on Wednesday.
Manchester City maintained their perfect start to the season with a 2-0 victory over promoted Watford as champions Chelsea suffered a shock 2-1 home defeat by Crystal Palace on Saturday.
Now only Inter stand in the way of a treble that would match Manchester United's still unique feat of 1999.
Frank Lampard hit four goals for Chelsea in a 7-1 demolition of Aston Villa to put the Londoners briefly on top of the English Premier League with 71 points before United responded with a 4-0 win in an evening game at Bolton Wanderers -- Dimitar Berbatov scoring twice for the champions.
Spain's path to European Championship success was forged the hard way thanks to a remarkable collective effort, with several squad players coming off the bench at key moments to make decisive contributions when the team needed them the most.
Protests erupted in Minneapolis and other US cities on Tuesday after George Floyd, an African-American man, died following his arrest by the police.
Images from the UEFA Champions League matches on Tuesday night.
Manchester United will all but retain their Premier League title on Saturday if they become the first English side to win at Stamford Bridge for four years. Even if United lose and allow Chelsea to pull level on points, Alex Ferguson's team would stay top with a superior goal difference of plus-54 compared to Chelsea's plus-36.
Images from the English Premier League matches played on Saturday.
The Premier League champions have endured a dismal season so far, losing eight of the 16 games they have played in all competitions, and were knocked out of the League Cup, that they also won last season, in a penalty shootout against Stoke City on Tuesday night.
Chelsea beat Manchester City 1-0 with a Michael Essien goal to move back up to second place in the Premier League on Sunday.
Chelsea found no chink in Everton's defensive armour as the Premier League champions were held to a frustrating 0-0 draw at Goodison Park on Saturday.
A summary of Saturday's action in the Premier League.
Runaway Premier League leaders Manchester City beat champions Chelsea 1-0 at the Etihad Stadium on Sunday to extend their lead to 18 points and leave the London side further adrift from the Champions League qualification spots.
West Ham United and Chelsea both narrowly avoided ignominious FA Cup exits with narrow wins against lower-league opposition but Everton marked Frank Lampard's first game in charge by sauntering past Brentford into the fifth round on Saturday.
Chelsea closed the gap on leaders Manchester United to two points by winning 2-0 at Manchester City on Saturday. The victory gave them 74 points from 33 matches and means the pressure will be on United when they travel to Middlesbrough for their game in hand on Sunday.
Manchester City clinched the Champions League title to seal their treble in a sensational season.
News of all that's transpired on and off the football field
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
Three consecutive draws for Chelsea allowed Manchester United to stride into 2007 six points clear at the top of the EPL table.
The Portuguese star was linked with a move away during the summer transfer window, though Manchester United coach Erik ten Hag said he still featured in his plans for the season.
Manager Andre Villas-Boas criticised referee Chris Foy after his Chelsea team had two players sent off in a shock 1-0 defeat at west London neighbours Queens Park Rangers on Sunday.
A goal in added time by Diego Costa earned Chelsea a 1-1 draw against Manchester United on Sunday and preserved Guus Hiddink's unbeaten record while denying Dutch compatriot Louis van Gaal victory.
A round-up of Wednesday's action in the UEFA Champions League
Premier League leaders Manchester United outclassed bottom side Watford 4-0 on Wednesday to maintain their six point lead over Chelsea, who beat Blackburn Rovers 3-0.
IMAGES from the English Premier League matches played on Saturday.
The result left Manchester United top of the EPL standings on 35 points, three ahead of Chelsea.
Chelsea cut Manchester United's Premier League lead to five points after Didier Drogba scored the winner in a 1-0 victory over Newcastle United on Wednesday.
Chelsea's hopes of retaining the Premier League title looked forlorn and Carlo Ancelotti's future equally bleak on Wednesday as the champions' fall from grace continued with a 1-0 defeat at Wolverhampton Wanderers.
Third-placed Chelsea will be eager to bounce back from their 1-0 defeat by relegation-threatened West Ham United on Saturday but face a tough test against a Huddersfield side that have won four and drawn two of their eight home league games this season.
Chelsea beat Newcastle United 2-0 for a 10th successive Premier League home win at their Stamford Bridge stronghold on Saturday to reassert themselves as Premier League leaders while champions Manchester City drew at Everton.
Peter Kenyon left his job as Manchester United chief executive to take the same position at their English premier league rivals Chelsea.
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